A new study has revealed that Pfizer’s Covid mRNA “vaccine” is linked to recent spikes in cases of Löfgren’s syndrome and plaque-type cutaneous sarcoidosis.
Löfgren’s syndrome, also known as acute sarcoidosis, is a specific form of sarcoidosis, which is a multisystem inflammatory disorder.
According to the National Institutes of Health (NIH), it presents with a characteristic triad of symptoms: bilateral hilar lymphadenopathy (swollen lymph nodes in the chest), erythema nodosum (a rash of painful, red bumps on the legs), and arthritis, especially in the ankles.
Other symptoms can include fever, joint pain or swelling, and eye inflammation.
A team of researchers led by Dr. Masahiro Oka and Dr. Kita-Harima Medical Center, and Dr. Takeshi Fukumoto of Kobe University in Japan, has just linked surging reports of Löfgren syndrome to mRNA injections.
Their peer-reviewed study was published in the journal Acta Dermato-Venereologica.
In the study, the researchers present what may be the first documented case of Löfgren’s syndrome (LS) that has been linked to the administration of a Pfizer Covid mRNA “vaccine.”
Even more striking, the patient went on to develop plaque-type cutaneous sarcoidosis nearly a year later, after apparent resolution of LS.
Plaque-type cutaneous sarcoidosis refers to a specific skin manifestation of sarcoidosis, characterized by raised, reddish-brown or purple patches (plaques) on the skin.
These plaques can be smooth or scaly and may occur anywhere on the body, but are commonly found on the face, scalp, arms, back, legs, and buttocks.
The case involves a 57-year-old Japanese woman who developed classic LS symptoms, including polyarthritis, erythema nodosum, and bilateral hilar lymphadenopathy.
She developed the symptoms within one week of receiving her first dose of the mRNA injection.
Although initially misdiagnosed with cellulitis, subsequent radiographic and histological evaluations confirmed noncaseating granulomas consistent with stage I sarcoidosis.
Despite symptomatic improvement with NSAIDs, the patient later developed scaly plaques on her lower legs, which were histologically confirmed as cutaneous sarcoidosis.
This case highlights a troubling trajectory: nearly a year after receiving the Pfizer mRNA vaccine and recovering from Löfgren’s syndrome, the patient developed plaque-type cutaneous sarcoidosis.
The finding suggests a delayed or relapsing immune dysregulation.
The researchers warn that this delay means more people who received Pfizer’s shots could start suffering from Löfgren’s syndrome and plaque-type cutaneous sarcoidosis.
Histological analysis confirmed noncaseating granulomas in both the lungs and skin, pointing to a systemic sarcoid response potentially triggered or exacerbated by “vaccination.”
Compounding the issue, the initial misdiagnosis as cellulitis, a frequent error in LS, underscores diagnostic blind spots and raises the possibility that similar post-vaccination inflammatory conditions may be underrecognized or misclassified.
While two prior LS cases linked to heterologous Covid injections (AstraZeneca and Moderna) were published in Vaccines (Rademacher et al., 2021), this is the first report implicating Pfizer’s mRNA “vaccine” alone.
Cutaneous sarcoidosis has been sporadically reported after Covid “vaccination” (Seol et al., 2024; McMahon et al., 2021), with most cases lacking long-term follow-up.
However, diagnoses of the disorder have surged since the “vaccines” were first rolled out for public use in early 2021, meaning the cause simply hasn’t been properly identified.
This report adds to a growing literature on systemic immune-mediated conditions following Covid mRNA “vaccination.”
It highlights the importance of dermatological vigilance, long-term follow-up, and histopathological confirmation in cases of delayed inflammatory reactions.
Regulators and clinicians should take note of sarcoidosis as an adverse reaction pattern.
The study underscores the need for more robust post-marketing surveillance systems capable of detecting rare but serious immune sequelae that may emerge long after initial “vaccine” exposure.
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